Molecular Basis for Adaptive Responses during Chemically Induced Hepatotoxicity
نویسندگان
چکیده
منابع مشابه
Molecular basis for adaptive responses during chemically induced hepatotoxicity.
Prior exposure to toxic xenobiotics can elicit changes within liver that confer resistance upon subsequent reexposure— a phenomenon sometimes referred to as autoprotection (Dalhoff et al., 2001; Thakore and Mehendale, 1991). Classically, the mechanisms underlying such responses have been assigned to either of two categories. First, so-called toxicodynamic alterations involve molecular changes w...
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bout one third of the agents established as carcinogenic to man have affinities for lung. These include defined compounds and the complex mixtures found in tars, oils, soot, car exhausts, and tobacco smoke.’ To understand mechanisms of initiation of these cancers, detailed studies of the biologic actions of specific classes of chemicals have been made. These have implicated DNA as a critical ta...
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ژورنال
عنوان ژورنال: Toxicological Sciences
سال: 2006
ISSN: 1096-6080,1096-0929
DOI: 10.1093/toxsci/kfj059